<i>In vitro</i> activity of human recombinant alpha-2b interferon against SARS-CoV-2 virus

Introduction. The pandemic spread of a new coronavirus infection, COVID-19, has caused global emergency and attracted the attention public health professionals population all countries. A significant increase in number cases SARS-CoV-2 infection demonstrates urgency finding drugs effective against this pathogen.The aim work was to evaluate vitro antiviral efficacy human recombinant alpha-2b interferon (IFN-?2b) virus.Material methods. experiments had been carried out on Vero Cl008, continuous line African green monkey (Chlorocebus sabaeus) kidney cells. effectiveness assessed by suppression viral reproduction vitro. biological activity determined using titration virus-containing suspension Cl008 cell culture formation negative colonies.Results. IFN-?2b-based medications, which have high safety profile proven prevention treatment influenza acute respiratory infections (ARVI), studied virus C1008 culture. IFN-?2b effectively inhibits when applied both 24 hrs before 2 after infection. In concentration range 102–106 IU/ml complete demonstrated.Discussion. demonstrated SARS-CoV-2. addition, substance chemotherapeutic index (1000).Conclusion. Medications for intranasal use based are promising vivo study terms COVID-19.